miRNA-regulated cancer stem cells: understanding the property and the role of miRNA in carcinogenesis

Over the last few years, microRNAs (miRNA)-controlled cancer stem cells have drawn enormous attention. Cancer stem cells are a small population of tumor cells that possess the stem cell property of self-renewal. Recent data shows that miRNA regulates this small population of stem cells. In the present review, we explained different characteristics of cancer stem cells as well as miRNA regulation of self-renewal and differentiation in cancer stem cells. We also described the migration and tumor formation. Finally, we described the different miRNAs that regulate various types of cancer stem cells, such as prostate cancer stem cells, head and neck cancer stem cells, breast cancer stem cells, colorectal cancer stem cells, lung cancer stem cells, gastric cancer stem cells, pancreatic cancer stem cells, etc. Extensive research is needed in order to employ miRNA-based therapeutics to control cancer stem cell population in various cancers in the future.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2016 Jul 28 [Epub ahead of print]

Chiranjib Chakraborty, Kok-Yong Chin, Srijit Das

Department of Bioinformatics, School of Computer and Information Sciences, Galgotias University, Uttar Pradesh, India., Department of Pharmacology, Universiti Kebangsaan Malaysia Medical Centre, 56000, Kuala Lumpur, Malaysia., Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, 56000, Kuala Lumpur, Malaysia. .