Aerobic glycolysis, known as the Warburg effect, is one of the hallmarks of cancer cells. We recently reported that the hexokinase 2 (HK2)-mediated Warburg effect is required for castration-resistant prostate cancer that is driven by Pten/p53 deficiency, suggesting that HK2 might be a therapeutic target for prostate cancer patients carrying PTEN and p53 mutations.
Molecular & cellular oncology. 2015 Apr 30*** epublish ***
Yibin Deng, Junxuan Lu
Laboratory of Cancer Genetics; The University of Minnesota Hormel Institute ; Austin, MN USA., Department of Biomedical Sciences; Texas Tech University Health Sciences Center School of Pharmacy ; Amarillo, TX USA.