Targeting hexokinase 2 in castration-resistant prostate cancer

Aerobic glycolysis, known as the Warburg effect, is one of the hallmarks of cancer cells. We recently reported that the hexokinase 2 (HK2)-mediated Warburg effect is required for castration-resistant prostate cancer that is driven by Pten/p53 deficiency, suggesting that HK2 might be a therapeutic target for prostate cancer patients carrying PTEN and p53 mutations.

Molecular & cellular oncology. 2015 Apr 30*** epublish ***

Yibin Deng, Junxuan Lu

Laboratory of Cancer Genetics; The University of Minnesota Hormel Institute ; Austin, MN USA., Department of Biomedical Sciences; Texas Tech University Health Sciences Center School of Pharmacy ; Amarillo, TX USA.

E-Newsletters

Newsletter subscription

Free Daily and Weekly newsletters offered by content of interest

The fields of GU Oncology and Urology are rapidly advancing. Sign up today for articles, videos, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.

Subscribe