Regeneration and Carcinogenesis - Beyond the Abstract

The destruction of malignant cells using various methods is the most important task of cancer treatment. Oncologists from around the world have achieved impressive results as of present when solving the problem of cancer. At the same time, eliminating tumor cells does not lead to the elimination of the causes of malignant growth, which creates the risk of recurrence of the disease.

The article ‚ÄúRegeneration and Carcinogenesis‚ÄĚ is dedicated to solving this second problem: how to promote regression of the causes of malignant growth in people older than 40 years old. 

A reduction in the stem cell pool and the subsequent violation of renovation of all tissues in people older than 40 years old lead to constant stimulation of growth zones by excessively produced cell growth factors. Constant and excessive stimulation of mitogenic activity becomes a cause of malignant growth in people older than 40 years old. The direct triggering factor is the local effect of carcinogens, chronic inflammation, or pre-existing hereditary factors (manifested on the background of increased mitogenic stimulation). Accordingly, restoration of the pool of stem cells by providing transfusion of mononuclear fraction of peripheral blood harvested from young donors with the same blood groups and sex as the patient can restore tissue regeneration and significantly reduce / normalize the formation of cell growth factors that stimulate mitogenic activity. This renewal of regeneration can supplement the methods of treatment used in oncology, thereby significantly increasing their effectiveness. Understanding the pathogenesis of malignant growth, we consider regeneration renewal to be the primary method of cancer prevention in people older than 40 years old.

Written By:

Alexander V. Pechersky, M.D., Ph.D.
Senior Lecturer, Department of Surgery, St. Petersburg Medical Academy of Post-Graduate Studies, 41, Kirochnaya St., St. Petersburg, 197373, Russia


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