Genomic Aberrations Drive Clonal Evolution of Neuroendocrine Tumors

Molecular features of castration-resistant neuroendocrine prostate cancer (CRPC-NE) are not well characterized. A recent study that investigated genomic aberrations of CRPC-NE tumors suggests their clonal evolution from CRPC adenocarcinoma.

Furthermore, the existence of a distinct DNA methylation profile in CRPC-NE implicates a critical role for epigenetic modification in the development of CRPC-NE.

Trends in endocrinology and metabolism: TEM. 2016 Mar 29 [Epub ahead of print]

Akash Kumar Kaushik, Arun Sreekumar

Verna and Marrs McLean Department of Biochemistry and Molecular Biology and Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, TX 77030, USA., Verna and Marrs McLean Department of Biochemistry and Molecular Biology and Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Cellular Biology and Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, TX 77030, USA; Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA. 

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