Increased expression of ESCO1 is correlated with poor patient survival and its role in human bladder cancer

There is increasing evidence suggesting that establishment of sister chromatid cohesion N-acetyltransferase 1 (ESCO1) was involved in tumorigenesis. However, its role in bladder cancer remains unclear.

In this study, we aimed to study the clinical correlation and biological significance of ESCO1 in bladder cancer. Our results showed that ESCO1 was significantly over-expressed in bladder cancer tissues compared with that in adjacent normal tissues. And, increased ESCO1 expression was significantly associated with higher grade (P < 0. 001), higher tumor stage (P = 0. 014), and multifocality (P = 0. 042). Kaplan-Meier analysis and Cox proportional hazards model were performed to determine the prognostic significance of ESCO1, and the results showed that ESCO1 is a useful prognostic marker for bladder cancer patients. Moreover, we found that ESCO1 knockdown inhibited the growth, migration, and invasion of bladder cancer cells. In conclusion, our findings indicated that ESCO1 may play an important role in human bladder cancer, and ESCO1 might serve as a novel target and prognosis factor for human bladder cancer.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2015 Nov 07 [Epub ahead of print]

Shiying Zhang, Jianye Li, Gaobiao Zhou, Dawei Mu, Jingmin Yan, Jizhang Xing, Zhiyong Yao, Haibo Sheng, Di Li, Chao Lv, Bin Sun, Quan Hong, Heqing Guo

Department of Urology, Air Force General Hospital of PLA, 30 Fucheng Road, Haidian Distinct, Beijing, 100142, China. , Department of Urology, Air Force General Hospital of PLA, 30 Fucheng Road, Haidian Distinct, Beijing, 100142, China. , Department of Urology, Air Force General Hospital of PLA, 30 Fucheng Road, Haidian Distinct, Beijing, 100142, China. , Department of Urology, Air Force General Hospital of PLA, 30 Fucheng Road, Haidian Distinct, Beijing, 100142, China. , Department of Urology, Air Force General Hospital of PLA, 30 Fucheng Road, Haidian Distinct, Beijing, 100142, China. , Department of Urology, Air Force General Hospital of PLA, 30 Fucheng Road, Haidian Distinct, Beijing, 100142, China. , Department of Urology, Air Force General Hospital of PLA, 30 Fucheng Road, Haidian Distinct, Beijing, 100142, China. , Department of Urology, Air Force General Hospital of PLA, 30 Fucheng Road, Haidian Distinct, Beijing, 100142, China. , Department of Urology, Air Force General Hospital of PLA, 30 Fucheng Road, Haidian Distinct, Beijing, 100142, China. , Department of Urology, Air Force General Hospital of PLA, 30 Fucheng Road, Haidian Distinct, Beijing, 100142, China. , Department of Urology, Air Force General Hospital of PLA, 30 Fucheng Road, Haidian Distinct, Beijing, 100142, China. , Department of Urology, Air Force General Hospital of PLA, 30 Fucheng Road, Haidian Distinct, Beijing, 100142, China. , Department of Urology, Air Force General Hospital of PLA, 30 Fucheng Road, Haidian Distinct, Beijing, 100142, China.  

PubMed