Insulin-like growth factor I and risk of incident cancer in elderly men - results from MrOS-Sweden

Studies of the association between circulating IGF-I and cancer risk have shown conflicting results. We have previously observed a U-shaped association between IGF-I and cancer mortality. The present study test the hypotheses of a U-shaped association between IGF-I and incident cancer.

Elderly men (2368), randomly recruited from the general community.

IGF-I was measured in a cohort of elderly men. Complete data for incident cancer was obtained from the Swedish Cancer Registry. Statistical analyses included Cox proportional hazards regressions with or without a spline approach.

369 participants had incident cancer after baseline. Prostate cancer was most frequent (n=140). There was no association between serum IGF-I and all cancer or prostate cancer incidence. However, there was a nonlinear association between IGF-I and non-prostate cancer incidence (p =

There was a significant nonlinear association between IGF-I and non-prostate cancer. No association between IGF-I and prostate cancer was observed. Future studies are warranted to further investigate this nonlinear association, including whether IGF-I concentration is a reproducible, and useful, risk marker of non-prostate cancer. This article is protected by copyright. All rights reserved.

Clinical endocrinology. 2015 Oct 06 [Epub ahead of print]

Daniel Carlzon, Johan Svensson, Max Petzold, Magnus K Karlsson, Östen Ljunggren, Mohammad-Ali Haghsheno, Jan-Erik Damber, Dan Mellström, Claes Ohlsson

Center for Bone and Arthritis Research at the Sahlgrenska Academy (CBAR), Institute of Medicine, University of Gothenburg, Gothenburg, Sweden. , Center for Bone and Arthritis Research at the Sahlgrenska Academy (CBAR), Institute of Medicine, University of Gothenburg, Gothenburg, Sweden. , Center for Applied Biostatistics at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. , Clinical and Molecular Osteoporosis Research Unit, Department of Orthopaedics and Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden. , Department of Medical Sciences, University of Uppsala, Uppsala, Sweden. , Department of Urology, Institute of Clinical Sciences, University of Gothenburg, Gothenburg, Sweden. , Department of Urology, Institute of Clinical Sciences, University of Gothenburg, Gothenburg, Sweden. , Center for Bone and Arthritis Research at the Sahlgrenska Academy (CBAR), Institute of Medicine, University of Gothenburg, Gothenburg, Sweden. , Center for Bone and Arthritis Research at the Sahlgrenska Academy (CBAR), Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.

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