Carbon-ion Radiotherapy for Prostate Cancer: Analysis of Morbidities and Change in Health-related Quality of Life

To prospectively evaluate the feasibility of carbon-ion radiotherapy (C-ion RT) for prostate cancer using a new compact-sized accelerator.

Seventy-six patients underwent C-ion RT at our center using a recommended dose fractionation of 57.

6 GyE in 16 fractions established at the National Institute of Radiological Sciences. Health-related Quality of Life (HRQOL) assessment was also performed using the Medical Outcome Study 8-items Short Form Health Survey (SF-8) questionnaire.

The median follow-up time was 51 months (range=8-58 months). Grade 2 gastrointestinal and genitourinary complications developed in 1 (1. 3%) and 5 (6. 6%) patients, respectively. Recurrences occurred in 4 patients, and the 4-year biochemical relapse-free rate was 94. 6%. The HRQOL scores after C-ion RT were objectively well-maintained.

Irrespective of the small number of patients of the study, C-ion RT for prostate cancer using the first commercial-based accelerator reproduced the toxicity outcomes at the NIRS.

Anticancer research. 2015 Oct [Epub]

Hitoshi Ishikawa, Hiroyuki Katoh, Takuya Kaminuma, Hidemasa Kawamura, Kazuto Ito, Hiroshi Matsui, Junko Hirato, Nobuaki Shimizu, Yutaka Takezawa, Hiroshi Tsuji, Kazuhiro Suzuki, Tatsuya Ohno, Takashi Nakano, GROUP FOR GENITOURINARY TUMORS AT GUNMA HEAVY ION MEDICAL CENTER

Department of Radiation Oncology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan  Heavy Ion Medical Research Center, Gunma University, Gunma, Japan. , Heavy Ion Medical Research Center, Gunma University, Gunma, Japan. , Heavy Ion Medical Research Center, Gunma University, Gunma, Japan. , Department of Urology, Gunma University Graduate School of Medicine, Gunma, Japan. , Department of Urology, Gunma University Graduate School of Medicine, Gunma, Japan. , Department of Pathology, Gunma University Graduate School of Medicine, Gunma, Japan. , Department of Urology, Gunma Cancer Center, Gunma, Japan. , Department of Urology, Isesaki Municipal Hospital, Isesaki, Gunma, Japan. , Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan. , Heavy Ion Medical Research Center, Gunma University, Gunma, Japan. , Heavy Ion Medical Research Center, Gunma University, Gunma, Japan. , Heavy Ion Medical Research Center, Gunma University, Gunma, Japan.

PubMed

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