Department of Pathology and Laboratory Medicine Medical, University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, United States.Hollings Cancer Center Medical, University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, United States.
We have previously found increased expression of thromboxane synthase (TXAS) and thromboxane receptor (TP) beta isoform in the tissues of patients with bladder cancer. Studies in cell lines and mice have indicated a potential significant role of the thromboxane signaling pathway in the pathogenesis of human bladder cancer. This study was designed to determine if the changes observed in the tissues of patients with bladder cancer were mirrored by changes in the urine of these patients. We found increased levels of thromboxane B2 (TXB2) the major metabolite of TXAS and increased levels of the TPβ receptor. These results raised the possibility that patients with bladder cancer may be followed for progression or remission of their disease by quantitation of these substances in their urine.
Moussa O, Ciupek A, Watson DK, Halushka PV. Are you the author?
Reference: Prostaglandins Other Lipid Mediat. 2011 Sep 29. Epub ahead of print.