The impact of hypertriglyceridemia on prostate cancer development in patients aged ≥60 years - Abstract

Department of Urology, Division of Clinical Research and DevelopmentDepartment of Pathology, Jikei University School of Medicine, Minato-ku, Tokyo, Japan.


Study Type - Aetiology (individual cohort) Level of Evidence 2b.

What's known on the subject? and What does the study add? Patients aged ≥60 years with high TG levels may be move vulnerable to the development of prostate cancer with aggressive biology. We urologists have to pay attention to select the treatment for patients aged ≥60 year with high TG levels.

To investigate the relationship between serum triglyceride (TG) levels and the incidence and characteristics of prostate cancer detected on biopsy.

We evaluated data from consecutive patients who underwent prostatic biopsy. Data analysed included age, total serum prostate-specific antigen (PSA) level, prostatic volume, body mass index (BMI), TG levels, and cholesterol-lowering medications.

We analysed data from 905 patients, including 528 (58.3%) with positive biopsy findings. Using 150 mg/dL as the threshold point of TG levels, multivariate analysis yielded an adjusted odds ratio (OR) reflecting the association of higher TG levels with prostate cancer diagnosis of 1.66 (95% confidence interval (CI) 1.21-2.29, P = 0.002).  Pearson correlation coefficient analysis including age, PSA level, prostatic volume, BMI and TG, showed TG level significantly correlated with BMI (r = 0.185, P < 0.001).  In the analysis by age intervals (≤ 59, 60-69, and ≥70 years), the association between high TG levels and positive biopsy findings was enhanced in the age groups 60-69 and ≥70 years (OR 2.10, 95% CI 1.31-3.37, P = 0.002 and OR 1.91, 95% CI 1.03-3.53, P = 0.039, respectively), but not in the group aged ≤ 59 years.  In patients aged ≥60 years, high TG levels were statistically significantly associated with a Gleason score of ≥8.

High TG levels correlated well with a higher incidence of prostate cancer, especially in patients aged ≥60 years. High TG levels were also associated with a Gleason score of ≥8 in this age group. Our results suggest that elderly patients with high TG levels may be more vulnerable to the development of prostate cancer with an aggressive biology.

Written by:
Hayashi N, Matsushima M, Yamamoto T, Sasaki H, Takahashi H, Egawa S.   Are you the author?

Reference: BJU Int. 2011 Aug 4. Epub ahead of print.
doi: 10.1111/j.1464-410X.2011.10358.x

PubMed Abstract
PMID: 21812901 Prostate Cancer Section