A systematic confirmation study of reported prostate cancer risk-associated SNPs in Chinese men - Abstract

Fudan-VARI Center for Genetic Epidemiology, School of Life Sciences, Fudan University, Shanghai, PR China.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD; Department of Urology, Huashan Hospital, Fudan University, Shanghai, PR China; Department of Urology, Suzhou Municipal Hospital, Suzhou, PR China; Department of Urology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, PR China; Department of Urology, The First Affiliated Hospital, Guangxi Medical University, Guangxi, PR China; Department of Urology, Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, PR China; State Key Laboratory of Genetic Engineering, Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, PR China; Department of Urology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China; Department of Urology, Pudong Gongli Hospital, Shanghai, PR China; Department of Urology, First People's Hospital, Suzhou University, Suzhou, PR China Department of Urology, Changhai Hospital, The Second Military Medical University, Shanghai, PR China; Shanghai Cancer Institute, Shanghai, PR China; Department of Epidemiology, School of Public Health, University of California, Los Angeles, CA; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA; School of Public Health, Shanghai Jiaotong University, Shanghai, PR China; Department of Molecular & Genetic Toxicology, School of Public Health, Cancer Center, Nanjing Medical University, Nanjing, PR China; Department of Urology, Wake Forest University School of Medicine, Winston-Salem, NC; Van Andel Research Institute, Grand Rapids, MI; Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, NC.

 

 

More than 30 prostate cancer (PCa) risk-associated loci have been identified in populations of European descent by genome-wide association studies (GWAS). We hypothesized that a subset of these loci may be associated with PCa risk in Chinese men. To test this hypothesis, 33 single nucleotide polymorphisms (SNPs), one each from the 33 independent PCa risk-associated loci reported in populations of European descent, were investigated for their associations with PCa risk in a case-control study of Chinese men (1,108 cases and 1,525 controls). We found that 11 of the 33 SNPs were significantly associated with PCa risk in Chinese men (P < 0.05). The reported risk alleles were associated with increased risk for PCa, with allelic odds ratios ranging from 1.12 to 1.44. The most significant locus was located on 8q24 Region 2 (rs16901979, P = 5.14×10(-9) ) with a genome-wide significance (P < 10(-8) ), and three loci reached the Bonferroni correction significance level (P < 1.52×10(-3) ), including 8q24 Region 1 (rs1447295, P = 7.04×10(-6) ), 8q24 Region 5 (rs10086908, P = 9.24×10(-4) ), and 8p21 (rs1512268, P = 9.39×10(-4) ). Our results suggest that a subset of the PCa risk-associated SNPs discovered by GWAS among men of European descent is also associated with PCa risk in Chinese men. This finding provides evidence of ethnic differences and similarity in genetic susceptibility to PCa. GWAS in Chinese men are needed to identify Chinese-specific PCa risk-associated SNPs.

Written by:
Liu F, Hsing AW, Wang X, Shao Q, Qi J, Ye Y, Wang Z, Chen H, Gao X, Wang G, Chu LW, Ding Q, Ouyang J, Gao X, Huang Y, Chen Y, Gao YT, Zhang ZF, Rao J, Shi R, Wu Q, Wang M, Zhang Z, Zhang Y, Jiang H, Zheng J, Hu Y, Guo L, Lin X, Tao S, Jin G, Sun J, Lu D, Lilly Zheng S, Sun Y, Mo Z, Xu J.   Are you the author?

Reference: Cancer Sci. 2011 Jul 14. Epub ahead of print.
doi: 10.1111/j.1349-7006.2011.02036.x

PubMed Abstract
PMID: 21756274

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