Effect of quinolinyl acrylate derivatives on prostate cancer in vitro and in vivo - Abstract

Department of Urology, University Hospital Charité, Campus Charité Mitte, Schumannstrasse 20/21, 10117, Berlin, Germany.


Quinolines and acrylates are chemical compounds which were previously described as potential antitumor agents. In this study, a series of seven new quinolinyl acrylate derivatives were synthesized and evaluated against human prostate cancer cells PC-3 and LNCaP in vitro and in vivo. The most effective compound (E)-methyl 2-(7-chloroquinolin-4-ylthio)-3-(4 hydroxyphenyl) acrylate reduced the viability in both cell lines in a time- and dose-dependent manner. Inhibitory effects were also observed on the adhesion, migration, and invasion of the prostate cancer cells as well as on the neoangiogenesis, clonogenic and MMP-9 activity. The effect in vivo was studied in PC-3 xenografts in nude mice. The results were concordant with the in vitro effects and showed decreased tumor growth in treated animals compared to controls. The study suggests the multi-target efficacy of the quinolinyl derivate against human prostate cancer cells and supports its potential therapeutic usefulness.

Written by:
Rodrigues JR, Charris J, Ferrer R, Gamboa N, Angel J, Nitzsche B, Hoepfner M, Lein M, Jung K, Abramjuk C.   Are you the author?

Reference: Invest New Drugs. 2011 Jul 12. Epub ahead of print.
doi: 10.1007/s10637-011-9716-3

PubMed Abstract
PMID: 21748298

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