Overexpression of MCM10 promotes cell proliferation and predicts poor prognosis in prostate cancer

Prostate cancer (PCa) is one of the most malignant tumors of the male urogenital system. There is an urgent need to identify novel biomarkers for PCa.

In this study, we evaluated the expression levels of MCM10 in prostate cancer by analyzing public datasets (including The Cancer Genome Atlas and GSE21032). Furthermore, loss of function assays was performed to evaluate the effects of MCM10 on cell proliferation, apoptosis, and colony formation. Furthermore, we performed microarray and bioinformatics analyses to explore the potential mechanisms of MCM10.

In the present study, we for the first time revealed MCM10 was significantly upregulated in PCa. Moreover, we found increased MCM10 expression was significantly associated with advanced clinical stage and high Gleason score PCa. Kaplan-Meier analysis demonstrated higher MCM10 expression was associated with a poorer patient prognosis in PCa. Furthermore, loss of function assays showed that MCM10 knockdown inhibited cell proliferation and colony formation, but promoted cell apoptosis. Additionally, we performed microarray and bioinformatics analysis and found MCM10 regulated PCa progression by regulating a series of biological processes including cancer, cell death, and apoptosis.

These results suggest that MCM10 may be a potential diagnostic and therapeutic target for PCa.

The Prostate. 2018 Aug 10 [Epub ahead of print]

Feilun Cui, Jianpeng Hu, Songyi Ning, Jian Tan, Huaming Tang

Department of Urology, The Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, P.R. China., Medical College of Jiangsu University, Zhenjiang, Jiangsu, P.R. China.

email news signup