Benign prostate hyperplasia (BPH) is one of the most common urological problems in mid-aged to elderly men. Risk factors of BPH include family history, obesity, type 2 diabetes, and high oxidative stress. The main medication classes for BPH management are alpha blockers and 5α-reductase inhibitors. However, these conventional medicines cause adverse effects. Lycogen™, extracted from Rhodobacter sphaeroides WL-APD911, is an anti-oxidant and anti-inflammatory compound. In this study, the effect of Lycogen™ was evaluated in rats with testosterone-induced benign prostate hyperplasia (BPH). Testosterone injections and Lycogen™ administration were carried out for 28 days, and body weights were recorded twice per week. The testosterone injection successfully induced a prostate enlargement. BPH-induced rats treated with different doses of Lycogen™ exhibited a significantly decreased prostate index (PI). Moreover, the Lycogen™ administration recovered the histological abnormalities observed in the prostate of BPH rats. In conclusion, these findings support a dose-dependent preventing effect of Lycogen™ on testosterone-induced BPH in rats and suggest that Lycogen™ may be favorable to the prevention and management of benign prostate hyperplasia.
International journal of molecular sciences. 2018 Apr 10*** epublish ***
Chiang-Ting Wang, Ya-Yun Wang, Wen-Sheng Liu, Chun-Ming Cheng, Kuo-Hsun Chiu, Li-Lian Liu, Xue-Zhu Liu, Zhi-Hong Wen, Ya-Huey Chen, Tsung-Ming Chen
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, 70 Lienhai Rd., Kaohsiung 80424, Taiwan. ., Department of Chemistry, Fu Jen Catholic University, New Taipei City 24205, Taiwan. ., Asia-Pacific Biotech Developing, Inc., Kaohsiung 80681, Taiwan. ., Department of Animal Pharmacology, Development Centre for Biotechnology, New Taipei City 22180, Taiwan. ., Department and Graduate Institute of Aquaculture, National Kaohsiung University of Science and Technology, No.142, Haijhuan Rd., Nazih Dist., Kaohsiung 81157, Taiwan. ., Department of Oceanography, National Sun Yat-sen University, Kaohsiung 80424, Taiwan. ., Marine Microorganism Ecological and Application Lab, Zhejiang Ocean University, Zhoushan 316004, China. ., Department of Marine Biotechnology and Resources, National Sun Yat-sen University, 70 Lienhai Rd., Kaohsiung 80424, Taiwan. ., Graduate Institute of Biomedical Science, China Medical University, Cancer Center Building 8F, No. 6, Hsueh-shih Road, Taichung 40477, Taiwan. ., Department and Graduate Institute of Aquaculture, National Kaohsiung University of Science and Technology, No.142, Haijhuan Rd., Nazih Dist., Kaohsiung 81157, Taiwan. .