Circulating tumor cells (CTC) represent a very small subpopulation of the cancer cells found in the bloodstream of patients in the metastatic phase of neoplastic disease. Due to the timeline of the disease, they are regarded as a negative prognostic marker. This study focused on determining CTC percentages; these values vary between different types of cancer. In addition to their diagnostic use, CTCs may also be used to treat the disease. Calculating CTC population size and analyzing their biology in patients in advanced stages of cancer may prove valuable in creating a molecular profile for the disease. This would strongly encourage diagnostics and enable personalized treatment. We here present an analysis of recent data on CTCs in urological cancers and their potential uses.
Folia histochemica et cytobiologica. 2017 Oct 10 [Epub ahead of print]
Martin Cegan, Christopher Kobierzycki, Katarina Kolostova, Imrich Kiss, Vladimir Bobek, Robert Grill
Department of Laboratory Genetics, University Hospital Kralovske Vinohrady, Prague, Czech Republic; Department of Histology and Embryology, Wroclaw Medical University, Wroclaw, Poland; 3rd Department of Surgery, Motol University Hospital and 1st Faculty of Medicine, Charles University, Prague, Czech Republic. .