The possibility of using photochemical internalization (PCI) to enhance the effects of the cytotoxic drug bleomycin is investigated, together with photophysical determination and outlines of a possible treatment for intravesical therapy of bladder cancer. In vitro experiments indicated that the employment of PCI technology using the novel photosensitizer TPCS2a® can enhance the cytotoxic effect of bleomycin in bladder cancer cells. Furthermore, experiments in an orthotopic in vivo bladder cancer model show an effective reduction in both the necrotic area and the bladder weight after TPCS2a based photodynamic therapy (PDT). The tumor selectivity and PDT effects may be sufficient to destroy tumors without damaging the detrusor muscle layer. Our results present a possible new treatment strategy for non-muscle invasive bladder cancer, with the intravesical instillation of the photosensitizer and bleomycin followed by illumination through an optic fiber by using a catheter.
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Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2017 Oct 03 [Epub ahead of print]
Odrun A Gederaas, Anders Johnsson, Kristian Berg, Rojlina Manandhar, Chetana Shrestha, Daniel Skåre, Ingvild Kinn Ekroll, Anders Høgset, Astrid Hjelde
Department of Clinical and Molecular Medicine, NTNU, Norwegian University of Science and Technology, N-7491 Trondheim, Norway. ., Department of Physics, NTNU, Norwegian University of Science and Technology, N-7491 Trondheim, Norway., Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo, Norway., Department of Circulation and Medical Imaging, NTNU, Norwegian University of Science and Technology, N-7491 Trondheim, Norway., PCI Biotech AS, Ullernchausséen 64, 0379, Oslo, Norway.