Pathology Imagebase - A Reference Image Database for Standardization of Pathology

Despite efforts to standardize histopathology practice through the development of guidelines, the interpretation of morphology is still hampered by subjectivity. We here describe Pathology Imagebase, a novel mechanism for establishing an international standard for the interpretation of pathology specimens.

The International Society of Urological Pathology (ISUP) established a reference image database through the input of experts in the field. Three panels were formed, one each for prostate, urinary bladder and renal pathology, consisting of 24 international experts. Each of the panel members uploaded microphotographs of cases into a non-public database. The remaining 23 experts were asked to vote from a multiple-choice menu. Prior to and while voting panel members were unable to access the results of voting by the other experts. When a consensus level of at least 2/3 or 16 votes was reached, cases were automatically transferred to the main database. Consensus was reached in a total of 287 cases across five projects on the grading of prostate, bladder and renal cancer and classification of renal tumours and flat lesions of the bladder. The full database is available to all ISUP members at Non-members may access a selected number of cases.

It is anticipated that the database will assist pathologists in calibrating their grading and will also promote consistency in the diagnosis of difficult cases. This article is protected by copyright. All rights reserved.

Histopathology. 2017 Jul 19 [Epub ahead of print]

Lars Egevad, John Cheville, Andrew J Evans, Jonas Hörnblad, James G Kench, Glen Kristiansen, Katia R M Leite, Cristina Magi-Galluzzi, Chin-Chen Pan, Hemamali Samaratunga, John R Srigley, Lawrence True, Ming Zhou, Mark Clements, Brett Delahunt, ISUP Pathology Imagebase Expert Panel

Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden., Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., University Health Network, Laboratory Medicine Program, Toronto General Hospital, Toronto, ON, Canada., Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital and Central Clinical School, University of Sydney, Sydney, New South Wales, Australia., Institute of Pathology, University Hospital Bonn, Bonn, Germany., Department of Urology, Laboratory of Medical Research, University of Sao Paulo Medical School, Sao Paulo, Brazil., Department of Anatomic Pathology, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA., Department of Pathology, Taipei Veterans General Hospital, Taipei, Taiwan., Aquesta Uropathology and University of Queensland, Brisbane, Queensland, Australia., Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Department of Pathology, University of Washington Medical Center, Seattle, WA, USA., Department of of Pathology, UT Southwestern Medical Center, Dallas, TX, USA., Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health sciences, University of Otago, Wellington, New Zealand.