Long term disease free survival with multimodal therapy in small cell bladder cancer

Small cell bladder cancer (SCBC) is an aggressive subtype accounting for less than 1 % of all bladder malignancies associated with rapid progression, early metastases formation and high mortality rates.

We present an unusual long term disease free survival of a 60 year-old man who was diagnosed with SCBC two and a half years ago. He underwent four cycles of cisplatin/etoposide chemotherapy as well as a prophylactic whole-brain radiotherapy followed by a radical cystoprostatectomy and ileal neobladder with extended pelvic lymphadenectomy. Since 33 months the patient is now recurrence-free.

In this case report, we were able to show that early multimodal therapy results in long term disease free survival, thus we highly recommend neoadjuvant chemotherapy as a part of multimodal management of a primary metastases-free, localized and surgically resectable SCBC.

European journal of medical research. 2016 Oct 13*** epublish ***

Isabel Heidegger, Gennadi Tulchiner, Georg Schäfer, Wolfgang Horninger, Renate Pichler

Department of Urology, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria. ., Department of Urology, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria., Division of General Pathology, Department of Pathology, Medical University Innsbruck, Innsbruck, Austria., Department of Urology, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria. .

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