BACKGROUND/AIMS - Because of rarity, role of chemotherapy of bladder adenocarcinoma are still unidentified. Therefore, we performed a retrospective analysis of the clinical features and chemotherapy outcomes of bladder adenocarcinoma.
METHODS - Eligible patients for this retrospective analysis were initially diagnosed with bladder adenocarcinoma and presented with a clinically no other primary site of origin. The collected data included age, gender, performance status, stage, hemoglobin, albumin, initial date of diagnosis, treatment modality utilized, response to treatment, presence of relapse, last status of patient, and last date of follow-up.
RESULTS - We retrospectively reviewed 29 patients, who were treated with chemotherapy for bladder adenocarcinoma at 10 Korean medical institutions from 2004 to 2014. The median age of patients was 58 years (range, 17 to 78) and 51.7% of the patients were female. Urachal adenocarcinoma was identified in 15 patients. Of 27 symptomatic patients, 22 experienced gross hematuria. Twelve patients were treated with 5-f luorouracil based chemotherapy, five were gemcitabine based, three were taxane and others. Thirteen of them achieved complete response (10.3%) or partial response (34.5%). Median progression-free survival (PFS) and overall survival (OS) for all patients were 10.6 months (95% confidence interval [CI], 9.5 to 11.6) and 24.5 months (95% CI, 1.2 to 47.8), respectively. The cases of urachal adenocarcinoma exhibited worse tendency in PFS and OS (p = 0.024 and p = 0.046, respectively).
CONCLUSIONS - Even though bladder adenocarcinoma had been observed moderate effectiveness to chemotherapy, bladder adenocarcinoma is a highly aggressive form of bladder cancer. PFS and OS were short especially in urachal carcinoma.
The Korean journal of internal medicine. 2016 Apr 06 [Epub ahead of print]
Moon Jin Kim, Young Sam Kim, Sung Yong Oh, Suee Lee, Young-Jin Choi, Young Mi Seol, Min Jae Park, Ki Hyang Kim, Lee Chun Park, Jung Hun Kang, In-Gyu Hwang, Soon Il Lee, Seung Taek Lim, Hyo Song Kim, Ho Yeong Lim, Sun Young Rha, Hyo-Jin Kim
Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea., Dong-A University Hospital, Busan, Korea., Dong-A University Hospital, Busan, Korea., Dong-A University Hospital, Busan, Korea., Pusan National University Hospital, Busan, Korea., Pusan National University Hospital, Busan, Korea., Pusan National University Yangsan Hospital, Yangsan, Korea., Inje University Busan Paik Hospital, Busan, Korea., Kosin University College of Medicine, Busan, Korea., Gyeongsang National University Hospital, Jinju, Korea., Chung-Ang University College of Medicine, Seoul, Korea., Dankook University College of Medicine, Cheonan, Korea., Konyang University Hospital, Daejeon, Korea., Yonsei University College of Medicine, Seoul, Korea., Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea., Yonsei University College of Medicine, Seoul, Korea., Dong-A University Hospital, Busan, Korea.