Aggressive muscle-invasive bladder cancer with sarcomatoid differentiation in a 10-year-old girl: A case report

The present study reports an unusual case of high-grade bladder cancer in a 10-year-old girl who complained of painless hematuria and urinary frequency. The tumor displayed sarcomatoid differentiation and an aggressive behavior, which required the administration of adjuvant chemotherapy.

However, the disease progressed and the patient succumbed 6 months after surgery. It is known that the majority of malignant bladder cancers in pediatric patients are low-grade and present at an early stage, whereas sarcomatoid differentiation in the setting of a high-grade urothelial carcinoma is indicative of a poor prognosis. It is important that gross hematuria in pediatric patients is investigated carefully. It is recommended that the management of urothelial neoplasia in young patients should be predominantly decided on the basis of the grade and stage of the tumor rather than the age of the patient.

Experimental and therapeutic medicine. 2016 Jan 20 [Epub]

Zijian Wang, Wei Xiong, Cizhong Pan, Liang Zhu, Xinjun Wang, Zhichao Huang, Xiaokun Zhao, Zhaohui Zhong

Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China., Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China., Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China., Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China., Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China., Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China., Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China., Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.

E-Newsletters

Newsletter subscription

Free Daily and Weekly newsletters offered by content of interest

The fields of GU Oncology and Urology are rapidly advancing. Sign up today for articles, videos, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.

Subscribe