Treatment options in non-muscle-invasive bladder cancer after BCG failure

Bladder cancer is the ninth-most prevalent cancer worldwide. Most patients with urothelial cell carcinoma of the bladder present with non-muscle-invasive disease and are treated with bacillus Calmette-Guérin (BCG) intravesical therapy.

Many of these patients experience disease recurrence after BCG failure. Radical cystectomy is the recommended treatment for high-risk patients failing BCG. However, many patients are unfit for or unwilling to undergo this procedure. We searched the published literature on the treatment of non-muscle-invasive bladder cancer (NMIBC) after BCG failure. We review current evidence regarding intravesical therapy with gemcitabine, mitomycin combined with thermo-chemotherapy, docetaxel, nab-paclitaxel, photodynamic therapy (PDT), BCG with interferon (IFN), and combination sequentially administered chemotherapy.

Indian journal of urology : IJU : journal of the Urological Society of India. 0000 [Epub]

Nathan A Brooks, Michael A O'Donnell

Department of Urology, The University of Iowa, Iowa, USA. , Department of Urology, The University of Iowa, Iowa, USA.

PubMed      Full Text Article

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