Trends of the risk of second primary cancer among bladder cancer survivors: a population-based cohort of 10,047 patients

To determine whether the risk of second primary cancer (SPC) among patients with bladder cancer (BCa) has changed over past years.

Data from ten French population-based cancer registries were used to establish a cohort of 10,047 patients diagnosed with a first invasive (T1 or greater) BCa between 1989 and 2004 and followed up until 2007.

A SPC was defined as the first primary cancer occurring at least two months after a BCa diagnosis. Standardized incidence ratios (SIRs) of metachronous SPC were calculated. Multivariate Poisson regression models were used to assess the direct effect of the year of BCa diagnosis on the risk of SPC.

The risk of new malignancy among BCa survivors was 60% higher than the general population (SIR=1. 60, 95% CI 1. 51-1. 68). Male patients presented a high risk of SPC of the lung (SIR=3. 12), head and neck (SIR=2. 19) and prostate (SIR=1. 54). In multivariate analyses adjusted on gender, age at diagnosis and follow-up, a significant increase of the risk of second cancer of the lung was observed over calendar year of BCa diagnosis (p for linear trend . 010), with a SIR increasing by 3. 7% for each year (95% CI 0. 9%-6. 6%). However, no particular trend was observed regarding the risk of second cancer of the head and neck (p=. 596) or the prostate (p=. 518).

As the risk of SPC of the lung increased between 1989 and 2004, this study contributes more evidence to support promotion of tobacco-cessation interventions among BCa patients. This article is protected by copyright. All rights reserved.

BJU international. 2015 Oct 15 [Epub ahead of print]

Joris Muller, Pascale Grosclaude, Bénédicte Lapôtre-Ledoux, Anne-Sophie Woronoff, Anne-Valérie Guizard, Simona Bara, Marc Colonna, Xavier Troussard, Véronique Bouvier, Brigitte Trétarre, Michel Velten, Jérémie Jégu

Registre des cancers du Bas-Rhin, Laboratoire d'Épidémiologie et de Santé Publique, EA3430, FMTS, Université de Strasbourg, 4 rue Kirschleger, 67085, Strasbourg,, France. , Registre des cancers du Tarn, 1, rue Lavazière, BP 37, 81001, Albi, France. , Registre du cancer de la Somme, Service Épidémiologie Hygiène et Santé Publique, CHU Nord, F-80054, Amiens, France. , Registre des tumeurs du Doubs et du Territoire de Belfort, EA3181, Centre Hospitalier Régional Universitaire Saint-Jacques, 25030, Besançon, France. , Registre général des tumeurs du Calvados, Cancers & Préventions - U 1086 Inserm, Centre François Baclesse, Avenue du Général Harris BP 5026, 14076, Caen 05, France. , Registre des cancers de la Manche, Centre Hospitalier Public du Cotentin, 46 rue du Val de Saire, 50102, Cherbourg-Octeville, France. , Registre des cancers de l'Isère, CHU de Grenoble, Pavillon E BP 217, 38043, Grenoble 9, France. , Registre des hémopathies malignes de Basse-Normandie, Unité Fonctionnelle Hospitalo- Universitaire n°0350, Centre Hospitalier Universitaire, Avenue de la Côte de Nacre, 14033, Caen, France. , Registre des tumeurs digestives du Calvados, Cancers & Préventions - U 1086 Inserm, Centre François Baclesse, Avenue du Général Harris BP 5026, 14076, Caen 05, France. , Registre des tumeurs de l'Hérault, Centre de Recherche, 208 rue des Apothicaires, 34298, Montpellier 5, France. , Registre des cancers du Bas-Rhin, Laboratoire d'Épidémiologie et de Santé Publique, EA3430, FMTS, Université de Strasbourg, 4 rue Kirschleger, 67085, Strasbourg,, France. , Registre des cancers du Bas-Rhin, Laboratoire d'Épidémiologie et de Santé Publique, EA3430, FMTS, Université de Strasbourg, 4 rue Kirschleger, 67085, Strasbourg,, France.

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