Finasteride Reduces Risk of Bladder Cancer in a Large Prospective Screening Study

The androgen receptor has been implicated in the development and progression of bladder cancer (BCa), largely based on studies of animal models. We investigated whether finasteride was associated with a reduced incidence of BCa as observed by self-report in the Prostate, Lung, Colorectal, and Ovarian cancer screening trial.

Cox proportional hazard regression analysis was performed to determine the association of finasteride use with time to diagnosis of BCa, controlling for age and tobacco use. Of the 72 370 male participants who met inclusion criteria, 6069 (8. 4%) had reported the use of finasteride. BCa was diagnosed in 1. 07% (65 of 6069) of those who reported finasteride compared with 1. 46% (966 of 66 301) of those who reported no use during the trial. In a multiple Cox regression analysis, self-reported use of finasteride was associated with a decreased risk of development of BCa (hazard ratio: 0. 634; 95% confidence interval, 0. 493-0. 816; p=0. 0004), controlling for age and smoking. Limitations of this study include that it is observational and not randomized, that many of the confounding variables for BCa, such as alcohol use, were not available for use in the analysis, and that finasteride use was by annual self-report, which is subject to missing values and error.

Finasteride is a common medication used to reduce the size of the prostate and to promote hair growth by manipulating testosterone in men. Men are more likely than women to develop bladder cancer (BCa), but our study noted that men using finasteride were less likely to have a BCa diagnosis.

European urology. 2015 Aug 27 [Epub ahead of print]

Edwin E Morales, Sonja Grill, Robert S Svatek, Dharam Kaushik, Ian M Thompson, Donna P Ankerst, Michael A Liss

Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. , Life Sciences Mathematics Unit, Technische Universitaet Muenchen, Munich, Germany. , Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. , Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. , Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. , Life Sciences Mathematics Unit, Technische Universitaet Muenchen, Munich, Germany. , Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.  

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