Impact of renal function of patients with advanced urothelial cancer on eligibility for first-line chemotherapy and treatment outcomes

The aim of the study is to clarify the clinical effects of first-line chemotherapy regimens for advanced urothelial cancer on clinical responses and survival of patients grouped by renal function.

In this multicenter retrospective cohort study, 345 urothelial cancer patients received systemic chemotherapy for metastatic or unresectable disease in 17 centers (2004-10).

Two hundred and forty-one patients were treated with methotrexate, vinblastine, doxorubicin and cisplatin/methotrexate, epirubicin and cisplatin (n = 136) or gemcitabine and cisplatin (n = 105) followed by carboplatin-based treatments, non-platinum treatments or other regimens After 2008, gemcitabine and cisplatin was the most frequently used regimen in patients with an estimated glomerular filtration rate

Gemcitabine and cisplatin provided favorable responses and survival in patients with estimated glomerular filtration rate ≥60 ml/min/1 73 m(2) but unsatisfactory oncological outcomes in patients with estimated glomerular filtration rate

Japanese journal of clinical oncology 2015 Jun 07 [Epub ahead of print]

Daishi Ichioka, Jun Miyazaki, Takamitsu Inoue, Susumu Kageyama, Mikio Sugimoto, Koji Mitsuzuka, Yoshiyuki Matsui, Yusuke Shiraishi, Hidefumi Kinoshita, Hironobu Wakeda, Takeshi Nomoto, Eiji Kikuchi, Hiroyuki Nishiyama

Department of Urology, Faculty of Medicine, University of Tsukuba, Tsukuba , Department of Urology, Faculty of Medicine, University of Tsukuba, Tsukuba , Department of Urology, Akita University Graduate School of Medicine, Akita , Department of Urology, Shiga University of Medical Science, Otsu , Department of Urology, Faculty of Medicine, Kagawa University, Kagawa , Department of Urology, Graduate School of Medicine, Tohoku University, Sendai , Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto , Department of Urology, Hyogo College of Medicine, Hyogo , Department of Urology and Andrology, Kansai Medical University, Hirakata , Department of Urology, Faculty of Medicine, University of Miyazaki, Miyazaki , Department of Urology, Tokai University School of Medicine, Isehara , Department of Urology, Keio University School of Medicine, Tokyo, Japan , Department of Urology, Faculty of Medicine, University of Tsukuba, Tsukuba nishiuro@md tsukuba ac jp

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