Nonresponse to neoadjuvant chemotherapy for muscle-invasive urothelial cell carcinoma of the bladder - Abstract

BACKGROUND: Cisplatin-based neoadjuvant chemotherapy (NC) is commonly used in the treatment of muscle-invasive urothelial cell carcinoma of the bladder (UC) and has been shown to improve survival. However, not all patients respond to NC, thus delaying the interval to potentially curative surgical therapy, risking disease progression and subjecting patients to potential morbidity from NC. In this study, we perform a retrospective analysis of patients who received NC prior to cystectomy to identify factors associated with nonresponse.

PATIENTS AND METHODS: We identified 80 patients with clinical T2 to T4, N0 to N1 UC of the bladder who received NC and underwent radical cystectomy. Nonresponse was defined as patients with higher pathologic T stage than clinical stage or patients with nodal involvement identified on final pathology.

RESULTS: Overall, 20% of patients were considered nonresponders. In multivariate analysis, age was predictive of nonresponse (Ptrend < .05). Compared with those < 60 years of age, those aged 60 to 69 years (odds ratio [OR], 2.9; 95% CI, 0.7-12) and those aged ≥ 70 (OR, 5.0; 95% CI, 0.9-28) had higher odds of nonresponse. Patients who received gemcitabine-carboplatin had higher odds of nonresponse compared with those who received gemcitabine-cisplatin (OR, 4.4; 95% CI, 0.8-21).

CONCLUSION: A subset of patients receiving NC prior to cystectomy will experience disease progression. Future study will need to better identify methods to distinguish individuals more likely to benefit from NC and those that should receive upfront cystectomy.

Written by:
Mossanen M, Lee F, Cheng H, Harris W, Shenoi J, Zhao S, Wang J, Champion T, Izard J, Gore JL, Porter MP, Yu EY, Wright JL.   Are you the author?
Department of Urology, University of Washington School of Medicine, Seattle, WA; Department of Medicine, Division of Oncology, University of Washington School of Medicine, Seattle, WA; Group Health, Seattle, WA; University of Utah, Salt Lake City, UT; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.

Reference: Clin Genitourin Cancer. 2013 Nov 12. pii: S1558-7673(13)00265-6.
doi: 10.1016/j.clgc.2013.10.002

PubMed Abstract
PMID: 24361053

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