Non-invasive diagnosis bladder cancer: New molecular markers and future perspectives - Abstract

Bladder cancer represents a very important entity in the field of urologic oncology.

At the time of diagnosis 70% of them are non muscle-invasive tumors with a very variable risk of recurrence and progression. These patients will require a periodic follow up, at least for 5 years, performing multiple cystoscopies and urine cytologies throughout their lifes. These diagnostic tests are either invasive or have a low sensitivity, a fact that has stimulated the search of non-invasive markers with high sensitivity for the diagnosis of bladder cancer. The great advantage in this neoplasia is the availability of a biologic sample such as urine, which being in close contact with the urothelium collects exfoliated cells, representing a valuable non invasive tool for the diagnosis and follow up of this neoplasias. In this article we try to perform a review of those markers for bladder cancer already marketed and under development, as well as future diagnostic perspectives.

Written by:
Musquera M, Mengual L, Ribal MJ.   Are you the author?
Servicio de Urologia y laboratorio de Biologia Molecular, Hospital Clinic, Universidad de Barcelona, Barcelona, Spain.

Reference: Arch Esp Urol. 2013 Jun;66(5):487-94.


PubMed Abstract
PMID: 23793766

Article in Spanish.

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