Role of whole-body staging computed tomographic scans for detecting distant metastases in patients with bladder cancer - Abstract

Department of Radiology, University Hospitals of Leicester NHS Trust, Leicester General Hospital, Leicester, UK.

Department of Health Sciences, University of Leicester, Leicester, UK.



This study aimed to establish the incidence of distant metastases on whole-body computed tomographic (CT) scans in patients with newly diagnosed bladder cancer and to determine whether there is a significant difference in the incidence of metastases in patients with superficial and muscle invasive cancers.

A total of 201 patients who had a proven histological diagnosis of transitional cell carcinoma of the bladder and a whole-body staging CT scan at diagnosis were identified from our MDT database during a 36-month period. Imaging was retrospectively reviewed with view to recording site, if any, of distant metastases.

Of 201 patients, 11 (5.5%) were found to have distant metastases on CT. In univariable models, staging was not associated with either age (odds ratio, 0.98; 95% confidence interval, 0.92-1.04; P = 0.4) or sex (Fisher exact test, P = 0.07). Mean (SD) age was 74.1 (10.5) years. There was a significant association between staging and metastasis (odds ratio, 19.9; 95% confidence interval, 3.2-infinity; P = 0.0003). Of the patients, 7% of males had metastases versus 0% of the females.

Staging CT scans for assessment of distant metastatic disease in patients with newly diagnosed bladder cancer can be restricted to patients with muscle invasive disease.

Written by:
Rajesh A, Sokhi H, Fung R, Mulcahy KA, Bankart MJ.   Are you the author?

Reference: J Comput Assist Tomogr. 2011 May-Jun;35(3):402-5.
doi: 10.1097/RCT.0b013e318214ad58

PubMed Abstract
PMID: 21586938 Bladder Cancer Section