The fifth-edition of World Health Organization (WHO) Classification of Tumors series for urinary and male genital tract tumors has been published, six years later the fourth-edition. In these years, new treatment approaches have been implemented and new molecular data on urological cancers are known. Morphology remains the groundwork for taxonomy of the urinary tract tumors. However, a molecular approach to classification of urothelial carcinomas and the management of selected neoplasms with new therapeutic modalities such as immunotherapy are emerging. More data are needed for the application of these advances in routine pathology practice and patient management. The 2022 World Health Organization (WHO) Classification of Tumors of the Urinary System and Male Genital Organs represents an update in classification on urinary tract tumors. It also offers new insights with regards to the grading of heterogeneous non-invasive urothelial neoplasms, the definition of inverted neoplasms, the grading of invasive urothelial carcinomas, the diversity of morphological appearance of urothelial carcinomas, the definition of precursor lesions and the lineage of differentiation of the tumors.
Pathologica. 2023 Jan 25 [Epub ahead of print]
Maria Rosaria Raspollini, Eva M Comperat, Antonio Lopez-Beltran, Rodolfo Montironi, Alessia Cimadamore, Toyonori Tsuzuki, George J Netto
Histopathology and Molecular Diagnostics, University Hospital Careggi, Florence, Florence, Italy., Department of Pathology, Medical University of Vienna, General Hospital of Vienna, Wien, AT, Austria., University of Cordoba, Cordoba, Spain., Molecular Medicine and Cell Therapy Foundation, Polytechnic University of the Marche Region, Ancona, Italy., Istituto di Anatomia Patologica, Dipartimento di Area Medica, Università di Udine., Department of Surgical Pathology, Aichi Medical University, Aichi, Japan., Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA.