Analysis of Complications after Robot-Assisted Radical Cystectomy between 2002-2021.

To identify trends in complications following robot-assisted radical cystectomy (RARC) using a multi-institutional database, the International Robotic Cystectomy Consortium (IRCC).

A retrospective review of the IRCC database was performed (2976 patients, 26 institutions from 11 countries). Postoperative complications were categorized as overall or high grade (≥ Clavien Dindo III) and were further categorized based on type/organ site. Descriptive statistics was used to summarize the data. Multivariate analysis (MVA) was used to identify variables associated with overall and high-grade complications.  Cochran-Armitage trend test was used to describe the trend of complications over time.

1777 (60%) patients developed postoperative complications following RARC, 51% of complications occurred within 30 days of RARC, 19% between 30-90 days, and 30% after 90 days. 835 patients (28%) experienced high-grade complications. Infectious complications (25%) were the most prevalent, while bleeding (1%) was the least. The incidence of complications was stable between 2002-2021. Gastrointestinal and neurologic postoperative complications increased significantly (p<0.01, for both) between 2005 and 2020 while thromboembolic (p=0.03) and wound complications (p<0.01) decreased. On MVA, BMI (OR 1.03, 95%CI 1.01-1.05, p<0.01), prior abdominal surgery (OR 1.26, 95%CI 1.03-1.56, p=0.03), receipt of neobladder (OR 1.52, 95%CI 1.17-1.99, p<0.01), positive nodal disease (OR 1.33, 95%CI 1.05-1.70, p=0.02), length of inpatient stay (OR 1.04, 95%CI 1.02-1.05, p<0.01) and ICU admission (OR 1.67, 95%CI 1.36-2.06, p<0.01) were associated with high-grade complications.

Overall and high-grade complications after RARC remained stable between 2002-2021. GI and neurologic complications increased, while thromboembolic and wound complications decreased.

Urology. 2022 Oct 11 [Epub ahead of print]

Holly Ann Houenstein, Zhe Jing, Ahmed S Elsayed, Yousuf O Ramahi, Michael Stöckle, Carl Wijburg, Abolfazl Hosseini, Peter Wiklund, Eric Kim, Jihad Kaouk, Prokar Dasgupta, Mohammed S Khan, Andrew A Wagner, Johar R Syed, James O Peabody, Ketan Badani, Lee Richstone, Alexandre Mottrie, Thomas J Maatman, Derya Balbay, Juan P Redorta, Koon Ho Rha, Franco Gaboardi, Morgan Rouprêt, Ahmed Aboumohamed, Ahmed A Hussein, Khurshid A Guru

Roswell Park Comprehensive Cancer Center., UKS Saarland., Rijnstate Hospital., Karolinska Institute., Washington University St. Louis., Cleveland Clinic., Guy's Hospital., Beth Israel Deaconess Medical Center., Henry Ford Health System., Icahn School of Medicine at Mount Sinai Hospital., Arthur Smith Institute for Urology., Orsi Academy., Metro Health Hospital., Koç University Hospital., Fundacio Puigvert., Yonsei Medical Health Care System., Luigi Sacco., Hôpital Pitié-Salpétrière., Montefiore Medical Center., Roswell Park Comprehensive Cancer Center. Electronic address: .