Bladder cancer histological variants: which parameters could predict the concordance between transurethral resection of bladder tumor and radical cystectomy specimens?

The concordance rate of bladder cancer (BCa) histological variants (HV) between transurethral resection of bladder tumor (TURBT) and radical cystectomy (RC) is sub-optimal and is unclear which factors may influence it. The aim of this study was to identify factors that may be correlated to a higher TURBT-RC concordance rate.

Consecutive patients who had undergone RC between 2000 and 2019 at a single Institution with pathological evidence of HV were included. Patients with diagnosis of HV both at RC and at the previous TURBT were enlisted in the TURBT-RC Concordance Group (CG), whereas patients with only evidence of HV at RC in the TURBT-RC Non-Concordance Group (NCG). Surgical factors evaluated were the source of energy (mono- vs bipolar), surgeon's experience (</≥100), execution of re-TURBT, number and size of specimens at TURBT.

A total of 81 patients were included, 49 (60.5%) in the CG and 32 (39.5%) in the NCG. Among the surgical factors, maximal core length (MCL) was significantly higher in the CG (12.5 vs 10 mm, p = 0.014) (Table 1). At uni- and multivariable analyses, MCL>10 mm represented an independent predictor of concordance [OR 2.95; CI (1.01-8.61); p = 0.048]. Tumor recurrence, focality and dimension, source of energy, surgeon's experience, performance of re-TURBT and total number of specimens at TURBT did not significantly predict the concordance.

Longer specimens at TURBT yield a higher chance to detect HV before RC. In this light, improving the quality of bladder resection means improving the management of BCa.

Central European journal of urology. 2021 Sep 09 [Epub]

Guglielmo Mantica, Stefano Tappero, Stefano Parodi, Nataniele Piol, Bruno Spina, Rafaela Malinaric, Federica Balzarini, Marco Borghesi, André Van Der Merwe, Nazareno Suardi, Carlo Terrone

Department of Urology, Policlinico San Martino Hospital, University of Genova, Genova, Italy., Department of Pathology, Policlinico San Martino Hospital, University of Genova, Genova, Italy., Department of Urology, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa.

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