To investigate to the incidence and mortality of BCG infections in Finnish population of patients with bladder cancer treated with BCG instillations.
We conducted a nationwide register study and identified patients with BCG infections in Finland during 1996-2016 using the Finnish cancer registry and the Finnish National Infectious Diseases Register. We estimated the number of patients treated with BCG instillations based on data on national consumed BCG doses used to treat bladder cancer patients and calculated the annual incidence proportion of BCG infections. We further performed a detailed medical chart review to describe the clinical features and outcomes of the treated BCG infections.
In total, 87 patients with BCG infection following BCG treatment of bladder cancer were identified. The incidence proportion increased gradually, yielding a cumulative incidence proportion of 2.5 % during the latter half of the study period. BCG infections harbored significant mortality with 10 % overall mortality and 17.5 % mortality in systemic infections, which is notably higher than previously reported.
The incidence proportion of BCG infections among bladder cancer patients treated with BCG has increased in Finland up to 2.5 % on a nationwide level with a notably higher mortality rate than previously reported.
BJU international. 2021 Oct 07 [Epub ahead of print]
Pertti Nurminen, Otto Ettala, Raija Uusitalo-Seppälä, Antti Nummi, Riikka Järvinen, Antti Kaipia, Peter J Boström
Department of Urology, Turku University Hospital, and University of Turku, Turku, Finland., Department of Infectious diseases, Satakunta Hospital district, Pori, Finland., Department of Urology, Helsinki University Hospital, Helsinki, Finland., Department of Urology, Tampere University Hospital, Tampere, Finland.