Detecting urine metabolites of bladder cancer by surface-enhanced Raman spectroscopy.

Metabolites present in urine reflect the current phenotype of the cancer state. Surface-enhanced Raman spectroscopy (SERS) can be used in urine supernatant or sediment to largely reflect the metabolic status of the body.

SERS was performed to detect bladder cancer (BCa) and predict tumour grade from urine supernatant, which contains various system metabolites, as well as from urine sediment, which contains exfoliated tumour cells.

Upon combining the urinary supernatant and sediment results, the total diagnostic sensitivity and specificity of SERS were 100% and 98.85%, respectively, for high-grade tumours and 97.53% and 90.80%, respectively, for low-grade tumours.

The present results suggest high potential for SERS to detect BCa from urine, especially when combining both urinary supernatant and sediment results.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2020 Oct 24 [Epub ahead of print]

Dayu Hu, Xiaosong Xu, Zeyin Zhao, Changqi Li, Ye Tian, Qiang Liu, Bo Shao, Shuo Chen, Yue Zhao, Ling Li, Huan Bi, Ang Chen, Cheng Fu, Xiaoyu Cui, Yu Zeng

College of Medicine and Biological Information Engineering, Northeastern University, No. 500 Wisdom Street, Shenyang 110169, China., Department of Urology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, 44 Xiaoheyan Road, Shenyang, Liaoning 110042, China., College of Medicine and Biological Information Engineering, Northeastern University, No. 500 Wisdom Street, Shenyang 110169, China; Key Laboratory of Data Analytics and Optimization for Smart Industry, Northeastern University, Wenhua Road, Shenyang 110819, China., College of Medicine and Biological Information Engineering, Northeastern University, No. 500 Wisdom Street, Shenyang 110169, China; Key Laboratory of Data Analytics and Optimization for Smart Industry, Northeastern University, Wenhua Road, Shenyang 110819, China. Electronic address: ., Department of Urology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, 44 Xiaoheyan Road, Shenyang, Liaoning 110042, China. Electronic address: .