Treatment and prognosis of bladder cancer patients with other primary cancers. A nationwide population-based study in the Bladder Cancer Data Base Sweden (BladderBaSe).

To study how patients with urinary bladder cancer (UBC) with previous or concomitant other primary cancers (OPC) were treated, and to investigate their prognosis.

Using nationwide population-based data in the Bladder Cancer Data Base Sweden (BladderBaSe), we analysed the probability of treatment with curative intent, and bladder cancer specific and overall survival in patients with UBC diagnosed in the period 1997 - 2014 with or without OPC. The analyses considered the patient's characteristics, UBC tumour stage at diagnosis and site of OPC.

There were 38689 patients, of which 9804 (25%) had OPC. Those with synchronous OPC more often had T2 and T3 tumours and clinically distant disease at diagnosis than those with UBC only. Patients with synchronous prostate cancer, female genital cancer and lower gastro-intestinal cancer were more often treated with curative intent than patients with UBC only. When models of survival were adjusted for age at diagnosis, marital status, education, year of diagnosis, CCI and T-stage, UBC-specific survival was similar to patients with UBC only, but overall survival was lower for patients with synchronous OPC, explained mainly by deaths in OPC primaries with a bad prognosis.

OPC is common in patients with UBC. Treatment for UBC - after or in conjunction with an OPC - should not be neglected and carries just as high probability of success as treatment in patients with UBC only. The needs of patients with UBC and OPC and optimisation of their treatment in light of their complicated disease trajectory are important areas of research.

BJU international. 2020 Aug 06 [Epub ahead of print]

Firas Aljabery, Fredrik Liedberg, Christel Häggström, Viveka Ströck, Abolfazl Hosseini, Truls Gårdmark, Amir Sherif, Tomas Jerlström, Per-Uno MalmströmMalmström, Oskar Hagberg, Lars Holmberg

Department of Clinical and Experimental Medicine, Division of Urology, Linköping University, Linköping, Sweden., Department of Urology, Skåne University Hospital, Malmö, Sweden., Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden., Department of Pelvic Cancer, Karolinska University Hospital, Stockholm, Sweden., Department of Clinical Sciences, Danderyd Hospital, Karolinska Institute, Stockholm, Sweden., Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden., Department of Urology, School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden., Department of Translational Medicine, Lund University, Malmö, Sweden.