Therapeutic Applications of Curcumin and its Novel Formulations in the Treatment of Bladder Cancer: A Review of Current Evidence.

Bladder cancer, a life-threatening serious disease, is responsible for thousands of cancer-associated death worldwide. Similar to other malignancies, standard treatments of bladder cancer, such as Chemo-radiotherapy are not efficient enough in the affected patients. It means that, according to recent reports in the case of the life quality as well as survival time of bladder cancer patients, there is a critical requirement for exploring effective treatments. Recently, numerous investigations have been carried out to search for appropriate complementary treatments or adjuvants for bladder cancer therapy. Curcumin, a phenolic component with a wide spectrum of biological activities, has recently been introduced as a potential anticancer agent. It has been showed that this agents exerts its therapeutic effects via targeting a wide ranges of cellular and molecular pathways involved in bladder cancer. Herein, we summarizes the current data on curcumin therapy for bladder cancer.

Anti-cancer agents in medicinal chemistry. 2020 Aug 07 [Epub ahead of print]

Mohammad Hossein Pourhanifeh, Reza Mottaghi, Zahra Sadat Razavi, Alimohammad Shafiee, Sarah Hajighadimi, Hamed Mirzaei

Halal Research Center of IRI, FDA, Tehran. Iran., Department of Oral and Maxillofacial Surgery, Kashan University of Medical Sciences, Kashan. Iran., School of Medicine, Kashan University of Medical Sciences, Kashan. Iran., Division of General Internal Medicine, Toronto General Hospital, Toronto, ON. Canada., Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan. Iran.