Increase in Circulating Tumor Cells in Invasive Bladder Cancer After Transurethral Resection of Bladder Tumor.

The present research was performed to clarify the differences in circulating tumor cells (CTCs) counts between non-muscle-invasive (NMIBC) and muscle-invasive (MIBC) bladder cancer following transurethral resection of bladder tumor (TURBT).

The cohort in the prospective research was categorized into the NMIBC (n=13) and the MIBC (n=13) groups. The pre- and postoperative number of CTCs was counted by the FISHMAN-R® system.

The difference of the number of preoperative CTCs between the NMIBC group (2.3±2.6) and MIBC group (4.8±4.2) did not reach statistical significance (p=0.08). However, there was a significantly greater increase in postoperative CTC count in the MIBC group (14.6±14.6) than in the NMIBC group (3.1±2.1, p=0.01).

After TURBT, more carcinoma cells can be discharged from the bladder in the MIBC. Excessive deep layer resection and excessive pressure of the infusion fluid during TURBT should be avoided in patients with MIBC.

Anticancer research. 2020 Aug [Epub]

Nobuhiro Haga, Kazuna Tsubouchi, Hiroko Maruta, Tomoyuki Koguchi, Seiji Hoshi, Soichiro Ogawa, Hidenori Akaihata, Junya Hata, Yoshiyuki Kojima

Department of Urology, Fukushima Medical University School of Medicine, Fukushima, Japan ., Department of Urology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan., Department of Urology, Fukushima Medical University School of Medicine, Fukushima, Japan.