The prognostic significance of hemoglobin-to-red cell distribution width ratio in muscle-invasive bladder cancer.

Aim: To investigate the prognostic significance of pretreatment hemoglobin (HB)-to-red cell distribution width (RDW) ratio (HRR) in patients with muscle-invasive bladder cancer (MIBC). Materials & methods: The neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), prognostic nutritional index, HRR, HB and RDW were analyzed to assess their prognostic value using the Kaplan-Meier curves and Cox-regression analysis in 152 patients with MIBC. Results: Univariate analysis showed that the progression-free survival (PFS) was associated with NLR, SII, HRR, RDW, whereas overall survival (OS) was associated with NLR, SII, prognostic nutritional index, HRR, HB, RDW. In multivariate analysis, HRR was found to be an independent prognostic factor for both PFS and OS. Conclusion: HRR is a new prognostic factor that can be used to predict PFS/OS in MIBC.

Biomarkers in medicine. 2020 Jul 10 [Epub ahead of print]

Ali Yılmaz, Hatice Yılmaz, Salim Başol Tekin, Mehmet Bilici

Department of Medical Oncology, Faculty of Medicine, Ataturk University, Yakutiye, Erzurum, Turkey., Department of Medical Oncology, Faculty of Medicine, Adnan Menderes University, Efeler, Aydın, Turkey.