Health-related quality of life overview after different curative treatment options in muscle-invasive bladder cancer: an umbrella review.

This umbrella review aims to evaluate the quality, summarize and compare the conclusions of systematic reviews investigating the impact of curative treatment options on health-related quality of life (HRQoL) in muscle-invasive bladder cancer (MIBC).

The Cochrane Library, MEDLINE, Embase and Web of Science were searched independently by two authors from inception until 06 January 2020. Systematic reviews and meta-analyses assessing the impact of any curative treatment option on HRQol in MIBC patients were eligible. Risk of bias was assessed using the AMSTAR 2 tool.

Thirty-two reviews were included. Robot-assisted RC with extracorporeal urinary diversion and open RC have similar HRQoL (n = 10). Evidence for pelvic organ-sparing RC was too limited (n = 2). Patients with a neobladder showed better overall and physical HRQoL outcomes, but worse urinary function in comparison with ileal conduit (n = 17). Bladder-preserving radiochemotherapy showed slightly better urinary and sexual but worse gastro-intestinal HRQoL outcomes in comparison with RC patients (n = 6). Quality of the reviews was low in more than 50% of the available reviews and most of the studies included in the reviews were nonrandomized studies.

This umbrella review gives a comprehensive overview of the available evidence to date.

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. 2020 Jun 06 [Epub ahead of print]

Elke Rammant, Lisa Van Wilder, Mieke Van Hemelrijck, Nele S Pauwels, Karel Decaestecker, Charles Van Praet, Renée Bultijnck, Piet Ost, Thomas Van Vaerenbergh, Sofie Verhaeghe, Ann Van Hecke, Valérie Fonteyne

Department of Human Structure and Repair, Ghent University, Corneel Heymanslaan 10, 9000, Ghent, Belgium. ., Department of Public Health and Primary Care, University Hospital, Ghent University, Ghent, Belgium., School of Cancer and Pharmaceutical Studies, Translational Oncology & Urology Research (TOUR), King's College London, London, UK., The Knowledge Center for Health Ghent, Ghent University, Ghent, Belgium., Department of Urology, Ghent University Hospital, Ghent, Belgium., Department of Human Structure and Repair, Ghent University, Corneel Heymanslaan 10, 9000, Ghent, Belgium., Department of Public Health and Primary Care, University Centre for Nursing and Midwifery, Ghent University, Ghent, Belgium., Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium.