Eosinophilic Leukemoid Reaction with Eosinophilic Tumor Tissue Infiltration as an Extermely Poor Prognostic Factor in Urinary Bladder Cancer- a Known Entity Revisited.

Eosinophilia can be a manifestation of a variety of causes such as infections, allergic reactions and autoimmune processes. Also, it is described in various solid malignancies in the presence of tumour eosinophilic infiltration. We report a patient of high-grade urinary bladder cancer with eosinophilic leukemoid reaction and tumour histopathology demonstrated diffuse infiltration of eosinophils. Though the entity is described to carry a good prognosis in literature, our experience is totally different as the patient deteriorated rapidly in a matter of days, was deemed inoperable in view of worsening performance status and was referred for palliative management.

Pathology oncology research : POR. 2020 Mar 29 [Epub ahead of print]

Bokka Sri Harsha, R Manikandan, K S Sreerag, L N Dorairajan, N G Rajesh, Rakhi Kar

Department of Urology and Renal Transplantation, JIPMER, Puducherry, India. ., Department of Urology and Renal Transplantation, JIPMER, Puducherry, India., Department of Pathology, JIPMER, Puducherry, India.