Reduced E-cadherin expression as a prognostic factor in non-muscle-invasive bladder cancer: A systematic review and meta-analysis.

The exact role of E-cadherin in non-muscle-invasive bladder cancer (NMIBC) is still unknown, and the aims of this study were to prove whether reduced E-cadherin expression can be a prognostic factor in patients with NMIBC.

A meta-analysis was conducted to assess the prognostic value of reduced E-cadherin expression in NMIBC. The PubMed, Embase and Web of Science databases were included in the study search.

Fifteen studies with a total of 1538 NMIBC patients were included. The results showed that reduced E-cadherin expression was significantly associated with poor recurrence-free survival (RFS) (pooled HR 2.16, 95% CI 1.22-3.85) and progression-free survival (PFS) (pooled HR 1.91, 95% CI 1.52-2.40) in NMIBC patients.

E-cadherin can be a prognostic factor for patients with NMIBC.

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie. 2020 Feb 12 [Epub ahead of print]

T Yang, J Fan, H Liang, D He, X Zeng, J Fan, K Wu

Department of Urology, First Affiliated Hospital of Xi'an Jiaotong University, 710061 Xi'an, PR China., Department of Pathology, First Affiliated Hospital of Xi'an Jiaotong University, 710061 Xi'an, PR China., Center for Evidence-Based and Translational Medicine, Zhongnan Hospital, Wuhan University, 430071 Wuhan, PR China., Department of Urology, First Affiliated Hospital of Xi'an Jiaotong University, 710061 Xi'an, PR China. Electronic address: .