Quality of life associated with orthotopic neobladder and ileal conduit in women: A multicentric cross-sectional study.

To compare quality of life and functional outcomes associated with orthotopic neobladder (ONB) and ileal conduit (IC) after anterior pelvic exenteration for bladder cancer in women, through a multicentric cross-sectional study.

All women who have undergone an anterior pelvic exenteration associated with ONB or IC for a bladder cancer between January 2004 and December 2014 within the three participating university hospital centers and that were still alive in February 2016 were included. Three distinct auto-administered questionnaires were submitted to the patients: the EORTC QLQ-C30, the EORTC QLQ-BLmi30 and the SF-12. Comparison of response to these questionnaires between women with ONB and those with IC were studied with Mann-Whitney U tests, with a statistically significant P-value set at<0.05. The primary endpoint was the "global health status" sub-score extracted from the EORTC QLQ-C30 questionnaire. The secondary endpoints were the functional sub-scores and symptoms sub-scores obtained with the EORTC QLQ-C30 questionnaire as well as the sub-scores obtained with the EORTC QLQ-BLmi30 and the SF-12 questionnaires.

Forty women were included in the study (17 ONB, 23 IC). The primary endpoint was comparable between the ONB and IC women (83.3 vs. 66.7 P=0.22). Similarly, no significant statistical difference could be pointed between the ONB and IC women in terms of secondary endpoints.

The present study did not report any significance difference in terms of quality of life and functional outcomes between women with ONB and those with IC after pelvic exenteration for bladder cancer.

3.

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie. 2020 Feb 12 [Epub ahead of print]

X Biardeau, N Lamande, L Tondut, B Peyronnet, G Verhoest, M Kyheng, M Soulie, X Game, J-C Fantoni, F Marcelli

Department of urology, CHU Lille, university Lille, Claude Huriez hospital, 59000 Lille, France. Electronic address: ., Department of urology, CHU Lille, university Lille, Claude Huriez hospital, 59000 Lille, France., Department of urology, Rennes university hospital, 35000 Rennes, France., EA2694, department of biostatistics, CHU Lille, 59000 Lille, France., Department of urology, Toulouse university hospital, Rangueil hospital, Toulouse, France.