Cytoplasmic linker-associated protein 2 (CLASP2) belongs to a family of microtubule plus-end tracking proteins that localize to the distal ends of microtubules and is involved in various microtubule-dependent processes. We previously showed that CLASP2 is involved in the epithelial-to-mesenchymal transition of bladder urothelial cancer. This research aimed to explore the significance of CLASP2 expression as a prognostic marker for muscle-invasive bladder urothelial cancer (MIBC) patients after radical cystectomy-pelvic lymph node dissection (RC-PLND).
CLASP2 expression was analyzed in 76 benign bladder tissues and 160 MIBC tissues by tissue immunohistochemistry. Survival analysis and multiple regression analysis following propensity score matching were performed to investigate the correlation between high CLASP2 expression and MIBC patients' survival.
CLASP2 expression was increased in MIBC patients, especially those with high-stage tumors or lymph node metastasis. In the follow-up of MIBC patients after propensity score matching, whether MIBC patients received adjuvant chemotherapy after RC-PLND, high CLASP2 expression was significantly associated with a poor prognosis. MIBC patients with low CLASP2 expression who received adjuvant chemotherapy tended to have an improved survival prognosis.
CLASP2 expression is correlated with malignant progression of MIBC. High CLASP2 expression predicted a poor prognosis for MIBC patients after RC-PLND.
Urologic oncology. 2019 May 23 [Epub ahead of print]
Lingxiao Chen, Wei Xiong, Wei Guo, Shitong Su, Lin Qi, Bisong Zhu, Miao Mo, Huichuan Jiang, Yuan Li
Department of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China., Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China., Department of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China. Electronic address: .