Molecular landscape of muscle-invasive bladder cancer: Patient age matter?

Dear editor, muscle-invasive urothelial bladder cancer (MIBC) is diagnosed in patients at a median age of approximately 70 years and is therefore, predominantly a disease of the elderly. This is likely due to an age-related accumulation of exposure to carcinogens such as tobacco smoke and occupational toxins, which are the main risk factors for this disease. Although the relative rate of non-muscle invasive bladder cancer is higher at earlier ages, younger patients can also acquire MIBC. Little is known about age-related differences in the molecule landscape MIBC. This article is protected by copyright. All rights reserved.

BJU international. 2019 May 09 [Epub ahead of print]

Roland Seiler, Alexander W Wyatt, Peter C Black

Department of Urology, Inselspital, Bern University Hospital, University of Bern, Switzerland., Vancouver Prostate Centre and Department of Urologic Sciences, University of British Columbia, Vancouver, Canada.