The Association between Metabolic Syndrome and High-Stage Primary Urothelial Carcinoma of the Bladder

Recently, metabolic syndrome (MetS) has become an important public health problem, and its prevalence is increasing. MetS is associated with multifactorial diseases. No reports have suggested a relationship between bladder cancer and high blood pressure, and hyperlipidemia has been reported as a possible risk factor. In the present study, we investigated the relationships between the stage and degree of malignancy of bladder cancer and MetS. Furthermore, we investigated the influence of the components of MetS on the results. We retrospectively analyzed the data of 169 patients who underwent transurethral resection of a bladder tumor in our department between Janurary 2005 and March 2011. MetS was significantly associated with a high histological grade (p < 0.05). MetS and low high-density lipo-protein were found to be significantly associated with the T stage; no other components of MetS were associated with a high stage or grade. Our results demonstrated that a lack of therapy for patients with low high-density lipoprotein levels could be riskier than was previously thought.

Current urology. 2018 Jun 30 [Epub]

Kei Nagase, Shohei Tobu, Shuhei Kusano, Kohei Takahara, Kazuma Udo, Mitsuru Noguchi

Department of Urology, Saga University Faculty of Medicine, Saga, Japan.