The standard of care in non-muscle invasive bladder cancer consists of transurethral tumor resection. The aim of this study was to evaluate the influence of transurethral resection of bladder tumor (TURB) on the patients' self-reported depression, anxiety, sexual satisfaction, and erectile dysfunction. Psychological condition of 252 male patients who underwent TURB was prospectively evaluated. The Hospital Anxiety and Depression Scale (HADS), simplified International Index of Erectile Function (IIEF-5), and Sexual Satisfaction Questionnaires (SSQ) were administered to patients before and 10 days after tumor resection. We found that primary anxiety, depression, and erectile dysfunction were all worse in cancer patients than those in the general population, and all further worsened after tumor resection. The post-resection worsening was influenced by the operation and catheterization time, complications, and the tumor characteristics. Taxonomical analysis shows that the greatest risk of depression aggravation concerned patients who were younger, had a higher body mass index, and a medium-sized tumor. We conclude that transurethral resection of non-muscle invasive bladder cancer may adversely affect sexual function, anxiety, and depression. Patients should be informed about potential complications to prevent the abandonment of a follow-up. The findings of this study stress the role of personalized medicine pursued by a multidisciplinary medical team.
Advances in experimental medicine and biology. 2018 Sep 23 [Epub ahead of print]
Wojciech Krajewski, Urszula Halska, Sławomir Poletajew, Radosław Piszczek, Bartosz Bieżyński, Mateusz Matyjasek, Andrzej Tukiendorf, Fryderyk Menzel, Małgorzata Mazur, Joanna Rymaszewska, Romuald Zdrojowy
Department of Urology and Oncological Urology, Wrocław Medical University, Wrocław, Poland. ., Department of Physiotherapy, Opole Medical School, Opole, Poland., Department of General, Oncological and Functional Oncology, Medical University of Warsaw, Warsaw, Poland., Department of Urology and Oncologic Urology, Lower Silesian Specialistic Hospital, Wrocław, Poland., Department of Urology and Oncological Urology, Wrocław Medical University, Wrocław, Poland., Department of Social Medicine, Wrocław Medical University, Wrocław, Poland., Department of Psychiatry, Wrocław Medical University, Wrocław, Poland.