"Utilization of BCG for Non-Muscle Invasive Bladder Cancer in an Era of BCG Supply Shortages"

To study trends in Bacillus Calmette-Guerin (BCG) utilization for non-muscle invasive bladder cancer (NMIBC) before and during national BCG shortages.

The National Cancer Database was used to identify patients with localized NMIBC. Multivariate logistic regression was used to assess factors associated with BCG use. Temporal trends in BCG use were studied using segmented regression analysis.

We identified 238,279 patients with NMIBC from 2004-2015. Overall, 33,660 (14.1%) patients with NMIBC received intravesical BCG during the study period. Segmented regression revealed a slower rate of rise of BCG utilization following major supply interruptions in 2011 and 2012 (2004-2012: +0.62% increase per year [p<.0001]; 2013-2015: +0.29% increase per year [p=0.084]). This trend was most pronounced in Ta-low grade patients and least pronounced in T1-high grade patients.

BCG utilization for NMIBC increased significantly over the study period, possibly representing increased adoption of national guidelines for BCG in NMIBC. In the years following interruptions in BCG supply, BCG use appears to have been rationed based on clinical risk, with the steepest declines in BCG use occurring in the lowest risk patients.

Urology. 2018 Sep 13 [Epub ahead of print]

Abhinav Khanna, Nitin Yerram, Hui Zhu, Simon Kim, Robert Abouassaly

Glickman Urologic and Kidney Institute, Cleveland Clinic, Cleveland OH. Electronic address: ., Glickman Urologic and Kidney Institute, Cleveland Clinic, Cleveland OH., Louis Stokes Cleveland VA Medical Center, Cleveland OH., University Hospitals Cleveland Medical Center, Cleveland OH., Glickman Urologic and Kidney Institute, Cleveland Clinic, Cleveland OH; Louis Stokes Cleveland VA Medical Center, Cleveland OH.