Insufficient specificity and invasiveness of currently used diagnostic methods raises the need for new markers of urological tumors. The aim of this study was to find a link between the urinary excretion of amino acids and the presence of urological tumors.
Using ion-exchange chromatography, we tested urine samples of patients with prostate cancer (n=30), urinary bladder cancer (n=28), renal cell carcinoma (n=16) and healthy volunteers (control group; n=21).
In each category, we found a group of amino acids which differed in concentration compared to the control group. These differences were most significant in sarcosine in patients with prostate cancer; leucine, phenylalanine and arginine in those with bladder cancer; and sarcosine, glutamic acid, glycine, tyrosine and arginine in the those with renal cell carcinoma.
Results of our research imply a possible connection between the occurrence of specific types of amino acids in the urine and the presence of urological tumors.
In vivo (Athens, Greece). 0000 Jan [Epub]
Katerina Duskova, Stepan Vesely, Joana DO Carmo Silva, Natalia Cernei, Ondrej Zitka, Zbynek Heger, Vojtech Adam, Klara Havlova, Marek Babjuk
Department of Urology, Second Faculty of Medicine, Charles University, and University Hospital Motol, Prague, Czech Republic ., Department of Urology, Second Faculty of Medicine, Charles University, and University Hospital Motol, Prague, Czech Republic., Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic.