A Diagnostic Approach to Adrenocortical Tumors.

Adrenocortical tumors range from primary bilateral micronodular or macronodular forms of adrenocortical disease to conventional adrenocortical adenomas and carcinomas. Accurate classification of these neoplasms is critical given the varied pathogenesis, clinical behavior, and outcome of these different lesions. Confirmation of adrenocortical origin, diagnosing malignancy, providing relevant prognostic information in adrenocortical carcinoma, and correlation of laboratory results with clinicopathologic findings are among the important responsibilities of pathologists who evaluate these lesions. This article focuses on a practical approach to the evaluation of adrenocortical tumors with an emphasis on clinical and imaging findings, morphologic characteristics, and multifactorial diagnostic schemes and algorithms.

Surgical pathology clinics. 2019 Sep 27 [Epub]

Anjelica Hodgson, Sara Pakbaz, Ozgur Mete

Department of Laboratory Medicine and Pathobiology, The University of Toronto, 1 King's College Circle, Medical Sciences Building, Toronto, Ontario M5S1A8, Canada., Department of Pathology, University Health Network, The University of Toronto, 200 Elizabeth Street, 11th Floor, Toronto, Ontario M5G2C4, Canada., Department of Pathology, University Health Network, 200 Elizabeth Street, 11th Floor, Toronto, Ontario M5G2C4, Canada; Department of Laboratory Medicine and Pathobiology, The University of Toronto, Toronto, Ontario, Canada. Electronic address: .