Risk of UTI in kidney stone formers: a matched-cohort study over a median follow-up of 19 years.

To describe risk of UTI in Stone formers comparing to non-stone formers.

Retrospective cohort study using electronic records for patients across southern England. Stone formers referred to a tertiary referral centre in Southern England, comparator patients were age and sex matched with 3:1 ratio from same database. Those with no documentation were excluded. UTI defined using ICD-10 codes. Risk of UTI presented as hazard ratio with 95% confidence interval, generated using cox regression. Sample size calculated using 80% power and significance set at 0.05.

Eight hundred and nineteen stone formers were included after 1000 records were screened for inclusion, with 2477 age and sex matched non-stone formers extracted from the same database. Sample size was calculated at 287 per group. Stone formers were at significantly increased risk of developing a UTI (HR 5.67; 95% CI 4.52-7.18, p < 0.001). Median follow-up was 19 years (IQR: 15-22).

Kidney stone formers are at increased risk of developing urinary tract infections.

World journal of urology. 2021 Jan 05 [Epub ahead of print]

Eleanor Brain, Robert M Geraghty, Paul Cook, Paul Roderick, Bhaskar Somani

Newcastle University Medical School, Newcastle-upon-Tyne, UK., Department of Urology, Freeman Hospital, Newcastle-upon-Tyne, UK. ., Department of Biochemistry, University Hospital Southampton, Southampton, UK., Department of Public Health, University of Southampton, Southampton, UK., Department of Urology, University Hospital Southampton, Southampton, UK.

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