The Impact of Prior Radiation Therapy on Artificial Urinary Sphincter Device Survival

Literature surrounding artificial urinary sphincter (AUS) device survival among individuals with a history of radiation therapy is conflicting. We aim to assess device survival outcomes among individuals with prior radiation therapy exposure undergoing primary AUS placement.

An Institutional Review Board approved database of all AUS patients from 1999-2011 was utilized to assess device survival in patients who underwent radiotherapy compared to individuals without radiotherapy exposure. Hazard regression and competing risk analysis was utilized to determine the association between radiation therapy and device outcomes.

From 1999-2011 a total of 872 patients underwent AUS surgery at our institution. Of these, 489 underwent primary AUS placement, with 181/489 (37%) having received radiation therapy. Patients with prior radiation therapy were older (median age 72. 0 vs 70. 1, p

While individuals who underwent radiation therapy were significantly older and had a higher BMI, device survival, was not significantly different between the two groups when utilizing a cuff size greater than 3. 5 cm. These findings will assist the urologist with preoperative counseling of men undergoing primary AUS placement with a history of radiation therapy.

The Journal of urology. 2015 Oct 27 [Epub ahead of print]

Marcelino E Rivera, Brian J Linder, Matthew J Ziegelmann, Boyd R Viers, Laureano J Rangel, Daniel S Elliott

Department of Urology, Section of Pelvic and Reconstructive Surgery, Mayo Clinic, Rochester, MN. , Department of Urology, Section of Pelvic and Reconstructive Surgery, Mayo Clinic, Rochester, MN. , Department of Urology, Section of Pelvic and Reconstructive Surgery, Mayo Clinic, Rochester, MN. , Department of Urology, Section of Pelvic and Reconstructive Surgery, Mayo Clinic, Rochester, MN. , Department of Urology, Section of Pelvic and Reconstructive Surgery, Mayo Clinic, Rochester, MN. , Department of Urology, Section of Pelvic and Reconstructive Surgery, Mayo Clinic, Rochester, MN.  

PubMed

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