Multi-factorial analysis of recurrence and complications of lingual mucosa graft urethroplasty for anterior urethral stricture: Experience from a Chinese referral center.

To evaluate the risk factors that pertain to stricture recurrence and oral complications.

Patients with long segmented anterior urethral stricture who visited our hospital from 2009 to 2016 were treated with lingual mucosa graft (LMG) urethroplasty. The incidence of complications in all of 128 patients were evaluated. The data were analyzed using the chi-squared test and Fisher's exact test. A multi-factorial regression analysis was performed to identify the risk factors responsible for the recurrence and complications.

For patients having LMG urethroplasty, there were no significant difference in recurrence of urethral stricture according to the studied variables. Binary logistic regression analysis reveals that previous surgery involving the urethra was a significant predictor of urethral stricture recurrence (odds ratio [OR]=5.07; 95% confidence interval [95% CI], 1.06-24.40; p=0.043). The length of the substitute was significantly related to oral morbidity (p=0.020), even after controlling for the studied variables. Patients with a harvested oral mucosa longer than 7 cm had a higher risk of oral morbidity than those with a harvested oral mucosa shorter than 7 cm (OR=4.35; 95% CI, 1.35-14.06; p=0.014).

Our study shows that LMG urethroplasty is effective for patients with long segmented anterior urethral stricture. Previous urethral surgery was identified as a risk factor to cause recurrence and injury to the tip of the tongue for the oral complications.

Urology. 2021 Mar 27 [Epub ahead of print]

Kaile Zhang, Tiantian Wang, Shiyi Cao, Lujie Song, Xiaoyong Hu, Jiong Zhang, Yuemin Xu, Qiang Fu

The Department of Urology, affiliated Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, China, 200233; Shanghai Eastern Institute of Urologic Reconstruction, Shanghai, China, 200233., School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, 430000., The Department of Urology, affiliated Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, China, 200233; Shanghai Eastern Institute of Urologic Reconstruction, Shanghai, China, 200233. Electronic address: .