Treatments of 1242 bulbar urethral strictures: multivariable statistical analysis of results

We investigated the success rate of different surgical techniques for bulbar stricture repair.

Retrospective study of patients with bulbar urethral strictures treated using different techniques. The primary outcome of the study was to evaluate the overall results of treatment (success vs. failure); the secondary outcome was to evaluate the outcome according to any surgical technique. Cysto-urethrography was performed 1 month following surgery. Patients underwent clinical evaluation, uroflowmetry and residual urine measurement every 6 months for 2 years after surgery and later once on year. When patient showed obstructive symptoms, Qmax < 12 ml/s, the urethrography was repeated. Patients who underwent further treatment for recurrent stricture were classified as failures. A bivariable and multivariable statistical analysis was performed.

Overall, 1242 patients were included in the study with mean age 40 years (range 12-84). Median stricture length was 4 cm (range 1-8). The median follow-up was 103 months (range 12-362). Over 1242 patients, 916 (73.8%) were success and 326 (26.2%) failures. Fourteen different surgical techniques showed a success rate ranging from 87.5 to 14.3%. The multivariable analysis showed that stricture length was an independent predictor factors for failure: p < 0.0001 CI 1146-1509. End-end anastomosis and oral mucosa graft urethroplasty are independent predictor factor of success after internal urethrotomy failure.

Our results showed that treatment of bulbar urethral stricture is satisfactory on 73.8% of patients, but with a wide range of success rate (from 14.3 to 87.5%) using different techniques. Oral mucosa is greatly superior to the skin as substitute material.

World journal of urology. 2018 Sep 15 [Epub ahead of print]

Guido Barbagli, Francesco Montorsi, Sofia Balò, Salvatore Sansalone, Carla Loreto, Denis Butnaru, Vittorio Bini, Massimo Lazzeri

Centro Chirurgico Toscano, Arezzo, Italy., Division of Oncology, Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy., Department of Experimental Medicine and Surgery, University of Tor Vergata, Rome, Italy., Department of Biomedical and Biotechnological Sciences, Section of Anatomy and Histology, University of Catania, Catania, Italy., Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, Moscow, Russia., Department of Internal Medicine and Biostatistic, University of Perugia, Perugia, Italy., Department of Urology, Humanitas Clinical and Researcher Center, Humanitas University, Rozzano, Italy. .